In a study published in Biomedicine & Pharmacotherapy, Fei et al., explored the potential of biocharBiochar is a carbon-rich material created from biomass decomposition in low-oxygen conditions. It has important applications in environmental remediation, soil improvement, agriculture, carbon sequestration, energy storage, and sustainable materials, promoting efficiency and reducing waste in various contexts while addressing climate change challenges. More to enhance the anti-cancer effects of butyrate-glycerides (BMDG) in colorectal cancer (CRC) cells. Colorectal cancer is a major global health concern, being the third most common cancer and the second leading cause of cancer-related deaths worldwide. The research focused on comparing biochar’s efficacy as a delivery mechanism for BMDG against activated carbonActivated carbon is a form of carbon that has been processed to create a vast network of tiny pores, increasing its surface area significantly. This extensive surface area makes activated carbon exceptionally effective at trapping and holding impurities, like a molecular sponge. It is commonly More, with the goal of improving targeted treatment options for CRC.  

The study revealed that BMDG, particularly when absorbed and delivered by biochar, significantly inhibited the proliferation of CRC cells. This effect was notably more pronounced in HCT116 cells, where biochar was observed to reduce glycolysis by up to 22%. Glycolysis is a metabolic process that aggressive cancer cells often rely on, known as the Warburg effect. By shifting the metabolic activity away from glycolysis and towards mitochondrial respiration, biochar helps to target a key vulnerability in these aggressive cancer cells.  

The researchers also noted that biochar has superior absorption and release properties compared to activated carbon, making it a more effective carrier for the anti-cancer compound. This enhanced delivery of butyrate-glycerides by biochar presents a promising strategy for the development of new oral drugs aimed at treating colorectal cancer by exploiting the Warburg effect.

SOURCE: Fei, L., Propato, A. P., Lotti, G., Nardini, P., Guasti, D., Polvani, S., Bani, D., Galli, A., Casini, D., Cantini, G., Chiaramonti, D., & Luconi, M. (2025). Tailor-made Biochar enhances the anti-tumour effects of butyrate-glycerides in colorectal cancer. Biomedicine & Pharmacotherapy, 184, 117900.